The obvious answer, of course, is to disable all your most-recently installed mods (the mods you installed since your last successful launch). Texture tearing, flickering, or shadow striping (normally conflicting texture packs).Crashing when carrying a particular item (weapon/armor mods).CTDs (crash-to-desktop) when loading specific zones/cells/towns/etc.There are loads of different ways to detect incompatibilities with Skyrim, and for sake of brevity, here's another list of common flags: Troubleshooting methodologies will vary based on use case scenarios, but let's assume that you - like many of us - installed numerous mods without checking for compatibilities after each successive installation.